Arterial Spin Labeling (ASL) is an MR technique using the water in arterial blood as an endogenous contrast agent to non-invasively evaluate perfusion. ASL is available as a 2D EPI sequence (ASL 2D) and as a 3D GRASE sequence (ASL 3D). ASL 2D includes inline calculation of relCBF maps for a quantitative evaluation of perfusion. ASL 3D includes an inline calculation of perfusion-weighted maps for a qualitative evaluation of perfusion. Clinical applications of ASL include acute stroke, evaluation of Transient Ischemic Cerebral Attack (TIA), chronic cerebrovascular disease, degenerative diseases like Alzheimer’s disease and frontotemporal dementia, evaluation of brain tumors, functional evaluation of the brain with BOLD techniques or intervention planning.
Arterial Spin Labeling as a Potential Biomarker in Imaging of Various Neurodegenerative Disorders
Sandhya Mangalore, MD; et al. (Dept. of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bengaluru, India)
Clinical Benefits of Multi-PLD PCASL in Pediatric Patients with Moyamoya Disease
Aya Tominaga et al., Miyagi Children’s Hospital, Sendai, Japan
Perfusion Imaging in Pediatric Brain Tumors: Pseudo-continuous Arterial Spin Labeling at Work
Giovanna Stefania Colafati et al., Department of Imaging, Neuroradiology Unit, Bambino Gesù Children’s Hospital, Rome, Italy
ASL perfusion imaging: Clinical experience in patients with cerebrovascular steno-occlusive disease
Toshibumi Kinoshita, et al., Department of Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels-Akita, Akita, Japan
Brain perfusion imaging in a case of thalamic stroke: a clinical application of 3D PCASL
Fabrizio Esposito, Ph.D. et al., Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno and Department of Diagnostic Imaging, University Hospital San Giovanni di Dio e Ruggi D’Aragona, Scuola Medica Salernitana, Salerno, Italy
Cerebral blood flow measurements in elderly using arterial spin labeling at 3T
Peter J. Joris, Ph.D. et al., Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands
3D ASL Perfusion: Biomarker of Activity in Japanese Encephalitis
Babu Peter Sathyanathan, M.D., D.N.B
Barnard Institute of Radiology, Madras Medical College, Chennai, India
Further readings
Contrast-free Quantitative CBF and Bolus Arrival Time using Multi-delay ASL Perfusion MRI
Qiao Penggang, et al., Department of Radiology, Affiliated Hospital of the Academy of Military Medical Sciences, Beijing, China
A novel 2D Pulsed Arterial Spin Labeling Protocol for Pediatric Cases with Brain Tumor
Yang Wang, M.D. et al., Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA
Arterial Spin Labeled Perfusion MRI
John A. Detre, M.D. Center for Functional Neuroimaging, Department of Neurology and Radiology, University of Pennsylvania, Philadelphia, PA, USA
Listen to the talks
Brain perfusion – acquisition and evaluation
Heiko Meyer, Siemens Healthineers, Erlangen, Germany
8th MAGNETOM World Summit, 2012
Clinical Applications of Arterial Spin Labeling
John A. Detre, University of Pennsylvania, Philadelphia, PA, USA
6th MAGNETOM World Summit, 2008
